(EE) CHEMISTRY, ORGANIC

Structure-activity relationship studies of biologically active peptides; design, chemical synthesis and biological activity of substrates and inhibitors of physiologically important enzymes – matriptase-2, matriptase-1, furin and proteasome; peptide conjugates with antimicrobial and anticancer activity – design and chemical activity; design and chemical synthesis peptides with enhance oral bioavailability

Human Cystatin C - conformational studies using NMR techniques and molecular dynamics
Study of the interaction of human cystine C with antibodies as potential amyloidosis inhibitors
Peptide antibiotics and peptidomimetics - design, synthesis, conformational studies
Peptides with pro-regenerative and neuroprotective properties - design, synthesis and physicochemical research
Design, synthesis and research of peptides with potential anti-cancer properties
Peptides and peptidomimetics in viral diseases

peptide synthesis; structure-activity relationship studies; design and synthesis of proproteinconvertases inhibitors; design, synthesis and investigations on biological activity of  human b-defensin analogues; utilization of capillary electroforesis (CE) for identification of substances with different chemical properties, practical aspects of CE utilization

- BIOTRANSFORMATIONS:

A) USING WHOLE MICROORGANISMS AS A WAY OF KNOWING THE METABOLIC PATHWAYS AND

B) AS A SYNTHETIC STRATEGY FOR OBTAINING ENANTIOMERICALLY PURE COMPOUNDS.

- DITERPENES AS A MODEL FOR NEW DRUGS
- BIOSYNTHETIC STUDIES INCORPORATING LABELLED INTERMEDIATES WITH STABLE ISOTOPES
- NEW DRUGS FROM MARINE MICROORGANISMS
- SYNTHESIS OF BIOACTIVE MOLECULES
- PHYTOPATHOGENIC FUNGAL TOXINS, EVALUATION OF THEIR INVOLVEMENT IN THE INFECTION PROCESS PRODUCED BY THE FUNGUS.

Isolation, functional evaluation, design and synthesis of drugs of natural origin.
Isolation, functional evaluation, design and synthesis of Agrochemicals of natural origin. Allelopathic studies in hihger plants and microorgnisms. Studioes of the structure-activity relationaships (SAR). Preparation of models of natural agrochemicals by partial and/ or total synthesis. Design of generalist and specific bioassys of phytotoxicity. Functional evaluation, design and preparation of functional foods

Synthesis of natural products with biological activity.
Isolation of natural products.

The aim of the scientific group is the development of multifunctional potentiometric sensors in solid state with membranes with the addition of nano particles. A secondary objective is to develop simple potentiometric sensors for the determination of chemical species of interest that would have improved properties. Improved sensor performance will be based on simpler preparation of samples for analysis (does not matter discoloration and turbidity of the sample), improved chemical, physical and electrical properties.