FQM188: EVOLUTIONARY VENOMICS AND SYNTHESIS OF BIOMOLECULES

Submitted by francisco.grimaldi on Tue, 08/25/2020 - 10:53
University
Faculty/school/department
SCIENCE FACULTY/MATERIALS SCIENCE AND ENG. MET/ INORGANIC CHEMISTRY
Size of the team
number of researchers number of supporting staff number of PhD students
7
0
0
Composition of Joint Unit of Research, if relevant

We carry out the synthesis and characterization of new organometallic compounds for use as catalysts in organic synthesis of bioactive molecules. We participate in expeditions (with CSIC-MNCN) to collect samples of venom ducts from cone snails for phylogenetic, transcriptomic and proteomic studies. Proteomic studies are carried out in our laboratory, by extraction of the venom and characterization by HPLC / MS. Attention is also paid to the role of small molecules as bioactive components of the venom.

PI
PI name
Manuel Jimenez Tenorio
PI bio

ORCID ID: 0000-0003-4088-4958

BSc in Chemistry (UCA, 1987) and PhD in Chemistry (Univ. of Sussex, Brighton, UK, 1991). Associate Professor (UCA, 1996), and Full Professor (UCA, 2016). Basic research on Organometallic Chemistry, and Evolutionary Venomics in recent years. Supervisor of de 3 PhD theses, 4 BSc theses, 1 MSc thesis, and 1 graduate thesis. Researcher in 36 Research Projects and Actions (National, Local and International Cooperation calls). Author of 97 publications in indexed journals and 5 books.  5 CNEAI six-year research periods recognised. Index h = 31, RG Score = 40.38, and 2742 citations in Google Scholar.

Contact person and e-mail
Contact person
Manuel Jimenez Tenorio
Contact person e-mail
WWW
Short description of research profile

Synthesis, characterisation and chemical reactivity of transition metal complexes for the activation of small molecules and C-C and C-H bonds, with application in organic synthesis: isomerization, cyclization, polymerisation, hydrogenation and dehydrogenation reactions, hydrodesulfuration, etc.
Taxonomy, phylogeny and genomics of venomous marine gastropods of the superfamily Conoidea. Evolutionary Venomics.

Publications

Representative publications

1. Conotoxin Diversity in the Venom Gland Transcriptome of the Magician's Cone, Pionoconus magus José R. Pardos-Blas, Iker Irisarri, Samuel Abalde, Manuel J. Tenorio and Rafael Zardoya Marine Drugs   (2019) Vol: 17. Pgs: 553- 
2. Activation of Propargyl Alcohols by TpRu Complexes Bearing a Bidentate NHC Ligand Manuel J. Tenorio; M. Carmen Puerta; Pedro Valerga Organometallics. 2016. Vol: 35. Núm: 3. Pgs. 388-399.
3. Atom-Economical Synthesis of the Versatile Ruthenium Precursor [TpRuCl(COD)] (Tp = Hydrotris(pyrazol-1-yl)borate) Discloses a Diamine Ligand Dealkylation Process Manuel J. Tenorio; M. Carmen Puerta; Pedro Valerga Organometallics. 2015. Vol: 34. Núm: 5. Pgs. 1001-1004.
4. Conotoxin Diversity in Chelyconus ermineus (Born, 1778) and the Convergent Origin of Piscivory in the Atlantic and Indo-Pacific Cones Samuel Abalde; Manuel J.Tenorio; Carlos M.L. Afonso; Rafael Zardoya Genome Biology and Evolution. 2018. Vol: 10. Núm:10. Pgs. 2643–2662.
5. Counteranion and Solvent Assistance in Ruthenium-Mediated Alkyne to Vinylidene Isomerizations Manuel Jiménez-Tenorio; M. Carmen Puerta; Pedro Valerga; Manuel A. Ortuño; Gregori Ujaque; Agustı́ Lledós Inorganic Chemistry. 2013. Vol: 52. Núm: 15. Pgs. 8919-8932.

Link to extended list of publication

Technology Expertise

Chemical synthesis under inert atmosphere
Handling of air- and moisture-sensitive chemicals
Nuclear Magnetic Resonance spectroscopy.
Chromatography and Mass spectrometry.
X-ray diffraction.
Geometric morphometrics.
World-renowned expertise in gastropods of the family Conidae