FQM169: ISOLATION, STRUCTURE DETERMINATION AND SYNTHESIS OF NATURAL PRODUCTS

Submitted by francisco.grimaldi on Tue, 08/25/2020 - 10:16
University
Faculty/school/department
SCIENCE FACULTY/ ORGANIC CHEMISTRY/ ORGANIC CHEMISTRY
Size of the team
number of researchers number of supporting staff number of PhD students
11
0
0
Composition of Joint Unit of Research, if relevant

Our group focuses its research on two areas of the study of natural products. On the one hand, the isolation and structure determination of new substances from algae, marine invertebrates, and plant species with biomedical interest. On the other hand, part of our efforts are focused on the discovery of new synthetic methodologies, which can be applied to the preparation of biologically interesting natural substances, according to current environmental concerns.

PI
PI name
Francisco Miguel Guerra Martinez
PI bio

ORCID ID: 0000-0001-8557-0018

Since He joined the research group, his work has been carried out along three main lines:
1) Isolation of new substances from natural sources: focused on different plant species, it has allowed the discovery of new metabolites with biological activity.
2) Total synthesis of complex organic molecules: mainly dedicated to the preparation of substances with interesting structural or biological properties.
3) Discovery of new methodologies in synthesis: aimed at the discovery of new methods for the activation of C-H bonds that can be applied to the total synthesis of complex molecules.

Contact person and e-mail
Contact person
Francisco Miguel Guerra Martinez
Contact person e-mail
WWW
Short description of research profile

Synthesis of natural products with biological activity.
Isolation of natural products.

Publications

Representative publications

1. Microwave-Enhanced Coupling of Carboxylic Acids with Liquid Ketones and Cyclic Ethers Using Tetrabutylammonium Iodide/t-Butyl Hydroperoxide Macías-Benítez, P.; Moreno-Dorado, F. J.; Guerra, F. M. Journal of Organic Chemistry   (2020) Vol: 85. Pgs: 6027-6043
2.  5-Alkylresorcinol derivatives from the bryozoan Schizomavella mamillata Ortega,M.J.; Pantoja, J. J.; de los Reyes,C.; Zubía, E. Marine Drugs, 2017, 15, 344
3.  A total synthesis prompts the structure revision of haouamine B.  Matveenko, M., Liang, G., Lauterwasser, E. M. W., Zubía, E., Trauner, D. Journal of the American Chemical Society,  2012, 134 (22), 9291-9295.
4. Acyloxylation of Cyclic Enones: Synthesis of Densely Oxygenated Guaianolides Marín-Barrios, R.; García-Cabeza, A. L.; Moreno-Dorado, F. J.; Guerra, F. M.; Massanet, G. M. Journal of Organic Chemistry, 2014, 79 (14), 6501-6509
5. Allylic Oxidation of Alkenes Catalyzed by a Copper-Aluminium Mixed Oxide García-Cabeza, A. L.; Marín-Barrios, R.; Moreno-Dorado, F. J.; Ortega, M. J.; Massanet, G. M.; Guerra, F. M Organic Letters, 2014, 16 (6), 1598–1601.

Link to extended list of publication

Technology Expertise

The group specializes in the following techniques:
- Structural elucidation techniques: nuclear magnetic resonance (mono- and two-dimensional), mass spectrometry and other spectroscopic techniques (IR and UV spectroscopy).
- Separation and isolation of substances: chromatographic techniques such as HPLC chromatography or gas chromatography.
- Reaction assembly: assembly of reactions in the absence of water and oxygen, use of microwave reactors, reaction monitoring by IR spectroscopy.