FQM286: Allelopathy in Hihger Plants and Microorgnisms

Submitted by francisco.grimaldi on Tue, 08/25/2020 - 12:53
Size of the team
number of researchers number of supporting staff number of PhD students
Composition of Joint Unit of Research, if relevant

Since our beginnings in studies of Allelopathy (1985) -study of the chemical language of plants- the group FQM-286, a pioneer in Europe, not only studies which specialized metabolites are involved in chemical interactions between plants and the ecosystem, but also in how their biological effects act and exert. Project full of new challenges through chemistry, the study of natural products, isolation, structural elucidation, partial and total synthesis, structure-activity relationship (SAR) studies, bioassays and recently nanoencapsulations and bioavailability, looking for applications in Agriculture and Pharmacology.

PI name
Francisco Antonio MACIAS DOMINGUEZ
PI email
PI bio

ORCID ID: 0000-0001-8862-2864

Since 2000 he has been a Professor of Organic Chemistry. He is currently Director of the Institute of Biomolecules (INBIO) since 2014. He has participated in 40 research projects / contracts from which the bioactivity of more than 3,000 allelochemical potentials and derivatives belonging to a wide range of chemical families to them have been isolated, identified, characterized, synthesized and tested, with application in agriculture and pharmacology. He is the author of 13 international patents. His publications, H-index 41, exceed 305, with book chapters; and has co-edited 2 books on Allelopathy. He has directed 32 PhD Theses and has given more than 375 conferences worldwide.

Contact person and e-mail
Contact person
Francisco Antonio MACIAS DOMINGUEZ
Contact person e-mail
Short description of research profile

Isolation, functional evaluation, design and synthesis of drugs of natural origin.
Isolation, functional evaluation, design and synthesis of Agrochemicals of natural origin. Allelopathic studies in hihger plants and microorgnisms. Studioes of the structure-activity relationaships (SAR). Preparation of models of natural agrochemicals by partial and/ or total synthesis. Design of generalist and specific bioassys of phytotoxicity. Functional evaluation, design and preparation of functional foods


Representative publications

1. Preparation and phytotoxicity evaluation of 11,13-dehydro seco-guaianolides Chinchilla, Nuria; Santana F., Alejandro; Varela, Rosa M.; Fronczek, Frank R.; Molinillo, José M.G.; Macías, Francisco A. Journal of Natural Products   (2019) Vol: 82. Pgs: 2501-2508
2. Complexation of Sesquiterpene Lactones with Cyclodextrins: Synthesis and Effects on their Activities on Parasitic Weeds Cala, Antonio; Molinillo, Jose M G; Fernandez-Aparicio, Monica; Ayuso, Jesús; Álvarez, José A.; Rubiales, Diego; and Macias, Francisco A. Organic & Biomolecular Chemistry. (2017), 15: 6500-6510.
3. Helikaurolides A-D, with a Novel Diterpene-Sesquiterpene Skeleton, from Supercritical Fluid Extracts of Helianthus annuus L. var Arianna Torres, Ascension; Molinillo, José M.G.; Varela, Rosa; M.; Casas, Lourdes; Mantell, Casimiro; Martinez de la Ossa, Enrique J. and Macias, Francisco A. Organic Letters (2015), 17: 4730-4733.
4. In Situ Eco Encapsulation of Bioactive Agrochemicals within Fully Organic Nanotubes. Mejías, Francisco J.R.; Trasobares, Susana; López-Haro, Miguel; Varela, Rosa M.; Molinillo, José M G; Calvino, José J.; Macias, Francisco A ACS Applied Materials & Interfaces. (2019), 11:41925-41934.
5. The Joint Action of Sesquiterpene Lactones from Leaves as explanation of the Activity of Cynara cardunculus Carlos Rial, Benito F. García, Rosa M. Varela, Ascensión Torres, José M.G. Molinillo, and Macias, Francisco A Journal of Agricultural and Food Chemistry (2016), 64: 6416-6424.

Link to extended list of publication

Technology Expertise

The group is an expert in extraction techniques for Natural Products (NP), conventional, natural and in supercritical conditions. In phytotoxicity, allelopathic, anti-parasitic plant, antibacterial, antifungal, cytotoxicity and bioavailability bioassay techniques. In structural elucidation techniques with IR, MS, UV, 1H and 13C NMR mono and two-dimensional. In separation techniques of NP by CC, FC, HPLC, UHPLC and CPC. In SAR and QSAR studies. In the design of interactions of Bioactive NP (BNP) with proteins via Docking studies. In partial and total synthesis of BNP. In BNP organic encapsulation: Polymer Nanoparticle, Supramolecular Polymer Micelle, Organic Nanotube, MOF, among others.