FQM295: Biological Chemistry: Biosynthetically Designed Fungicides

Submitted by moderator_UC on Tue, 08/25/2020 - 13:05
University
Faculty/school/department
SCIENCE FACULTY/ORGANIC CHEMISTRY/ORGANIC CHEMISTRY
Size of the team
number of researchers number of supporting staff number of PhD students
11
0
0
Composition of Joint Unit of Research, if relevant

The group currently carries out research in three major research areas funded by regional and national agencies:
- Study of the control of infections produced by phytopathogenic fungi, especially Botrytis cinerea and in recent years Eutipa lata.
- Diterpenes as models in the design of new drugs
- Metabolomic study of marine microorganisms in the search for new drugs

PI
PI name
Isidro Gonzalez Collado
PI bio

ORCID ID: 0000-0002-8612-0593

Graduate in Chemistry from the University of Seville (1978), Doctorate from the University of Cadiz (UCA) in November 1984. Two postdoctoral stays: at the Institute of Natural Products of the CSIC, La Laguna (Tenerife), and at the University of Sussex, Brighton, UK, in 1985 and 1986, respectively. "Visiting professor" at the University of Oxford, 1990 and Reading, 2005.
Professor at the University of Cádiz 1987-2000. Professor of the Dept. of Organic Chemistry at the UCA, 2000-continue.
Author of more than 220 international publications and 7 book chapters. He has directed 27 doctoral theses. He has an H index of 40, and has six six-year periods of research.

Contact person and e-mail
Contact person
Isidro Gonzalez Collado
Contact person e-mail
WWW
Short description of research profile

- BIOTRANSFORMATIONS:

A) USING WHOLE MICROORGANISMS AS A WAY OF KNOWING THE METABOLIC PATHWAYS AND

B) AS A SYNTHETIC STRATEGY FOR OBTAINING ENANTIOMERICALLY PURE COMPOUNDS.


- DITERPENES AS A MODEL FOR NEW DRUGS
- BIOSYNTHETIC STUDIES INCORPORATING LABELLED INTERMEDIATES WITH STABLE ISOTOPES
- NEW DRUGS FROM MARINE MICROORGANISMS
- SYNTHESIS OF BIOACTIVE MOLECULES
- PHYTOPATHOGENIC FUNGAL TOXINS, EVALUATION OF THEIR INVOLVEMENT IN THE INFECTION PROCESS PRODUCED BY THE FUNGUS.

Publications

Representative publications

1. The current status on secondary metabolites produced by plant pathogenic Colletotrichum species. Javier Moraga, Wesley Gomes, Cristina Pinedo, Jesús M. Cantoral, James R. Hanson,  María Carbú, Carlos Garrido,  Rosa Durán-Patrón, Isidro G. Collado Phytochemistry Reviews   (2019) Vol: 18. Pgs: 215-239
2. A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries Samuel Domínguez-García, Noelia Geribaldi-Doldán, Ricardo Gómez-Oliva, Felix A. Ruiz, Livia Carrascal, Jorge Bolívar, Cristina Verástegui, Monica Garcia-Alloza, Antonio J. Macías-Sánchez, Rosario Hernández-Galán, Pedro Nunez-Abades* and Carmen Castro* Cell Death and Disease 2020, 11, 262-281
3. Biologically active diterpenes containing a gem-dimethylcyclopropane subunit: an intriguing source of PKC modulators. Duran-Pena, Maria Jesus; Botubol Ares, Jose Manuel; Collado, Isidro G.; Hernandez-Galan, Rosario. Natural Product Reports (2014), 31(7), 940-952
4. Biosynthesis of abscisic acid in fungi: Identification of a sesquiterpene cyclase as the key enzyme in Botrytis cinerea. Inmaculada Izquierdo-Bueno, Victoria E. González-Rodríguez, Adeline Simon, Bérengère Dalmais, Jean-Marc Pradier, Pascal Le Pêcheur, Alex Mercier, Anne-Sophie Walker, Carlos Garrido, Isidro González Collado and Muriel Viaud. Environmental Microbiology (2018), 20(7), 2469-2482
5. Chemically Induced Cryptic Sesquiterpenoids and Expression of Sesquiterpene Cyclases in Botrytis cinerea Revealed New Sporogenic (+)-4-Epieremophil-9-en-11-ols Cristina Pinedo, Javier Moraga, Javier Barua, Victoria E. González-Rodríguez, Josefina Aleu, Rosa Durán-Patrón, Antonio J. Macías-Sánchez, James R. Hanson, Muriel Viaud, Rosario Hernández-Galán, Carlos Garrido, and Isidro G. Collado. ACS Chemical Biology (2016), 11,1391-1400

Link to extended list of publication

Technology Expertise
  • Isolation and synthesis of secondary metabolites
  • Structural characterization of bioactive molecules
  • Synthesis of organic molecules.
  • Genetic and molecular bases of the biosynthesis of bioactive molecules
  • Chromatographic and spectroscopic techniques and organic synthesis.
  • Molecular coupling studies (Docking) for drug design.
  • Antibiotic and fungicide activity tests