cancer

The Chromosome Segregation in Disease Laboratory investigates the canonical and non-canonical functions of mitotic proteins and their contribution to human disease. We study how proteins classically associated with chromosome segregation acquire additional roles, and how their dysfunction drives rare neurodevelopmental disorders and cancer.

Our laboratory is primarily focused on elucidating the molecular mechanisms that enable cancer cells to develop resistance to multiple anticancer therapies. In particular, we investigate the TRIBBLES family of pseudokinases and their contribution to tumor initiation, progression, and therapeutic resistance.

http://www.mefst.unist.hr/research/research-groups-and-laboratories/laboratory-for-biochemistry/4975