Bioinformatics

Understanding mechanisms of action of small proteins and peptides in biological systems. As a part of a large international (Poland, South Korea, USA, Argentina, France, Sweden) informal research group we participate in a project to develop what is called a coarse-grained (simplified) model of polypeptide chain called UNRES (UNited RESidues). (www.unres.pl)

Search and study of short peptide sequences having a defined spatial structure and showing the ability to catalyze chemical reactions.

Philip’s main scientific interest is to contribute to an understanding of the complex interactions between human intestinal mucosa and the environment in health and disease. The group focuses on the delineation of signaling pathways and cellular responses evoked by physiological and pathological host-microbe interaction in the intestinal epithelium and uses a broad range of model organisms from mice to bivalves to answer the questions. Of particular interest are events that are mediated via innate immune receptors (NLRs) or involve ER stress and autophagic responses, including: