Olivera Politeo, Natural Science, Chemistry (chemical analysis, antioxidant potential and enzyme
activity of plant extracts and pure compounds); Mladen Milos, Natural Science, Chemistry
(Investigation of the role of phenylboronic acid as a mediator in cellular delivery of natural bioactive
compounds); Mila Radan, Natural Science, Chemistry (antiproliferative activity of natural
compounds , metabolomic profiling of cultured cancer cells); Vladimir Jelaska Relja, technical
assistence.
The main topic of research of our group is the chemical composition and biological potential of
Dalmatian aromatic and medicinal plants. The chemical composition of volatile extracts is
performing by using GC-MS-MS system, while the composition of nonvolatile extracts is performing
by using HPLC-DAD and LC-MS-MS. Among the biological potential of plant extracts and pure natural
compounds our research group is testing the antioxidant potential, the enzyme inhibition potential
(AChE, BuChE, alpha-glucosidase,..), the cytotoxic and apopoptic effect. The aim of our research to
be find new plant extract as well as pure natural compound with strong biological effect on human
health.
GC-MS-MS; HPLC-DAD; LC-MS-MS; Spectrophotometer Multiplate Reader Tecan and Sinergy HTX Multimode Reader
F. Burčul, I. Blaževic, M. Radan, O. Politeo, Terpenes, phenylpropanoids, sulfur and other essential oil constituents as inhibitors of cholinesterases, Curr. Med. Chem. 19 (2018) 1-46. https://doi.org/10.2174/0929867325666180330092607
F. Burcul, I. Generalic Mekinic, M. Radan, P. Rollin, I. Blazevic, Isothiocyanates: cholinesterase inhibiting, antioxidant, and anti-inflammatory activity, J. Enzym. Inhib. Med. Chem. 33 (2018) 557–582. https://doi.org/10.1080/14756366.2018.1442832
D. Vullo, M. Milos, B. Galic, A. Scozzafava, C. T. Supuran, Dipotassium-trioxohydroxytetra fluoro triborate, K2[B3O3F4OH], is a potent inhibitor of human carbonic anhydrases, J. Enzyme Inhib. Med. Chem. 30 (2015) 341 – 344.
O. Politeo, M. Bektasevic, I. Carev, M. Jurin, M. Roje. Phytochemical Composition, Antioxidant Potential and Cholinesterase Inhibition Potential of Extracts from Mentha pulegium L. Chemistry & Biodiversity, 15 (12) (2018). https://doi.org/10.1002/cbdv.201800374
I. Carev, M. Ruscic, M. Skocibusic, A. Maravic, S. Siljak-Yakovlev, O. Politeo. Phytochemical and cytogenetic characterisation of Centaurea solstitialis L. (Asteraceae) from Croatia. Chemistry & Biodiversity 14, 2, 2017, 1-11. https://doi.org/ 10.1002/cbdv.201600213