CTS597: NEURODEGENERATION AND NEUROREPARATION

Submitted by francisco.grimaldi on Thu, 07/30/2020 - 13:21
University
Faculty/school/department
FACULTY OF MEDICINE/ BIOMEDICINE, BIOTECHNOLOGY AND PUBLIC HEALTH/PHYSIOLOGY
Size of the team
number of researchers number of supporting staff number of PhD students
17
0
0
PI
PI name
BERNARDO LOPEZ MORENO
PI bio

ORCID ID: 0000-0003-2897-6227

Born in a small village at Seville (Bollullos de la Mitación) in 1968, I obtained a degree in Biological Sciences at the University of Seville in 1992. I began my research formation in the Neuroscience Laboratory of the Department of Animal Physiology at the Biological Sciences School. I achieved my PhD in Biological Sciences at the University of Seville in 1997 with the defense of a research work carried out as the result of a collaboration between the Autonomous University of Madrid and the University of Seville. In 1998, I joined the University of Cadiz with a postdoctoral fellowship. Later, I obtained a position of University School Lecturer in 1999 that it became an University Lecturer in 2008. Finally, since 2016 I am Full Professor in the discipline of Human Physiology. I became an independent senior researcher at 2002 and in 2007 I founded, as the Chairman, the Neurodegeneration and Neurorepair Group (CTS597).

Contact person and e-mail
Contact person
BERNARDO LOPEZ MORENO
Contact person e-mail
WWW
Short description of research profile

Neurotransmission, synaptic plasticity and synaptopathies
Physiopathology of motor systems
Mechanisms underlying neuron sensitization to degenerate
Identification and development of feasible therapeutic strategies for treatment of several motor pathologies and neurodegenerative diseases.

Publications

Representative publications

1. Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1. García-Morales V, Rodríguez-Bey G, Gómez-Pérez L, Domínguez-Vías G, González-Forero D, Portillo F, Campos-Caro A, Gento-Caro Á, Issaoui N, Soler RM, Garcera A, Moreno-López B. Nature Communications Nature Publishing Group (2019) Vol: 10(1). Pgs: 3784- 
2. Cannabinoid agonists rearrange synaptic vesicles at excitatory synapses and depress motoneuron activity in vivo. García-Morales V, Montero F, Moreno-López B. Neuropharmacology. 2015 May;92:69-79.
3. Endogenous Rho-kinase signaling maintains synaptic strength by stabilizing the size of the readily releasable pool of synaptic vesicles González-Forero D, Montero F, García-Morales V, Domínguez G, Gómez-Pérez L, García-Verdugo JM, Moreno-López B. J Neurosci. 2012 Jan 4;32(1):68-84.
4. Membrane-derived phospholipids control synaptic neurotransmission and plasticity. García-Morales V, Montero F, González-Forero D, Rodríguez-Bey G, Gómez-Pérez L, Medialdea-Wandossell MJ, Domínguez-Vías G, García-Verdugo JM, Moreno-López B. PLoS Biol. 2015 May 21;13(5):e1002153.
5. Nitric oxide induces pathological synapse loss by a protein kinase G-, Rho kinase-dependent mechanism preceded by myosin light chain phosphorylation. Sunico CR, González-Forero D, Domínguez G, García-Verdugo JM, Moreno-López B. J Neurosci. 2010 Jan 20;30(3):973-84

Link to extended list of publication

Technology Expertise

qRT-PCR and Western Blotting
Interferent RNA technology applied to in vitro specimens and in live animals.
Primary cultures of spinal cord motoneurons obtained from mouse embryos.
Electrophysiological recordings of field and unique cell in in vitro samples and in the entire animal
Calcium imaging in culture cells
Immunohistochemistry
Intracerebral administration of oligonucleotides and drugs
Microiontophoresis in the central nevous system
Transgenic model of ALS disease: SOD1G93A
Knockout mice: task1-/-, task3-/-, task1-/-/task3-/-