CTS927: Diabetes, Growth and Development

Submitted by francisco.grimaldi on Thu, 07/30/2020 - 14:28
University
University of Cadiz
Faculty/school/department
FACULTY OF MEDICINE/ MATERNAL-CHILD AND RADIOLOGY/PEDIATRY
Size of the team
number of researchers number of supporting staff number of PhD students
16
0
0
PI
PI name
ALFONSO LECHUGA SANCHO
PI email
alfonso.lechuga@uca.es
PI bio

ORCID ID: 0000-0001-5861-6041

Pediatrician, in charge of the Pediatric Endocrinology and Diabetes unit at Puerta Del Mar University Hospital. Associate Professor in Pediatrics at Cadiz University, at the Mother and Child Health and Radiology Department. Head of the University Research group “Diabetes, Growth and Development”, and of the group “Inflammation, Metabolism and Oxidation” at INiBICA. I have directed 6 Doctoral Thesis (2 in basic research in Diabetes, and 4 in clinical research in obesity, neonatal CNS damage, diabetic retinopathy and general pediatrics). PI in national and local research proyects.

Contact person and e-mail
Contact person
ALFONSO LECHUGA SANCHO
Contact person e-mail
alfonso.lechuga@uca.es
WWW
https://cts927.uca.es/
Short description of research profile

- In vivo antioxidant octivity of functional foods. Development of biochemical techniques for the in vivo analysis of the true antioxidant activity of different foods when ingested.
- Study of the role of the placenta in gestacional diabetes and/or obesity, and the oxidative, notrosative and inflammatory damage to which it is subject in these circustances.
- Mechanism of action of oxidative and Inflammatory damage induced by nutrition in childhood obesity and other chronic inflammatory conditions
- Cerebral Neuroimaging
- Neuroimaging processing
- Neurocognitive profile in preterm infants
- Pulmonary Ultrasounds
- Sedation and alagesia in pediatric critical care
- Diagnostic and prognostic biomarkers in severe diseases, subsidiary of neonatal or pediatric critical care.

Research area
MEDICAL AND HEALTH SCIENCES » Clinical medicine
Scientific Themes (keywords)
OXIDATIVE AND NITROSATIVE STRESS; CHILDHOOD OBESITY; DIABETES; ANTIOXIDANT DEFENSES; Energy metabolism; INFLAMMATION; NEONATOLOGY; PREMATURITY; Neurodevelopment; NEUROIMAGE; BIOMEDICAL IMAGE PROCESSING; PULMONARY ECHOGRAPHY; BIOMARKER
Publications

Representative publications

1. Altered plasma-type gelsolin and amyloid-β in neonates with hypoxic-ischaemic encephalopathy under therapeutic hypothermia. Benavente-Fernandez I, Ramos-Rodriguez JJ, Infante-Garcia C, Jimenez-Gomez G, Lechuga-Sancho A, Lubian-Lopez S, Garcia-Alloza M Journal of cerebral blood flow and metabolism   (2019) Vol: 39. Pgs: 1349-1354
2. Association of Fluid Overload With Clinical Outcomes in Critically Ill Children With Bronchiolitis: Bronquiolitis en la Unidad de Cuidados Intensivos Pediátricos (BRUCIP) Study Flores-González, JC; Valladares, CM; Yun Castilla, C; Mayordomo-Colunga, J; Quesada, SP; Martín Delgado, CM; Goñi-Orayen, C; Fernández Carrión, F; Veiga, AM; Olmedilla-Jodar, M; Alcaraz Romero, AJ; Eizmendi-Bereciartua, M; Gutierrez, CS; Luján, EA; Navarro-Mingorance, Á; Jordán, I; Bronquiolitis en la Unidad de Cuidados Intensivos Pediátricos (BRUCIP) WorkGroup. Pediatr Crit Care Med. 2019 Mar;20(3):e130-e136
3. Intervention and Observational Trials are Complementary in Metabolomics: Diabetes and the Oral Glucose Tolerance Test. Gonzalez-Dominguez, A; Lechuga-Sancho, AM; Gonzalez-Dominguez, R. Curr Top Med Chem. 2018;18(11):896-900
4. Normal Cerebellar Growth by Using Three-dimensional US in the Preterm Infant from Birth to Term-corrected Age. Benavente-Fernández, I; Rodríguez-Zafra, E; León-Martínez, J; Jiménez-Gómez, G; Ruiz-González, E; Fernández-Colina, RC; Lechuga-Sancho, AM; Lubián-López, SP. Radiology. 2018 Jul;288(1):254-261
5. Obesity induced alterations in redox homeostasis and oxidative stress are present from an early age. Lechuga-Sancho, AM; Gallego-Andujar, D; Ruiz-Ocaña, P; Visiedo, FM; Saez-Benito, A; Schwarz, M; Segundo, C; Mateos, RM. PLoS One. 2018 Jan 25;13(1):e0191547.

Link to extended list of publication

https://cts927.uca.es/publicaciones-en-revistas/
Technology Expertise

Enzimatic activity analysis
Biomolecules quantification (Spectrophotommetry, ELISA, Multiplex)
Immunocytochemistry and immunohstochemistry
Proteomics
Metabolomics
Continuos insulin infusion
Continuos glucose monitoring
Amplitude integrated electroencephalography
Trasnfontanellar ultrasounds
Pulmonary Ultrasounds
Cranial Magnetic Resonance imaging
Pediatric sedo-analgesia