Pi, Phd and Master Students.
The overall objectives of the Epigenetics and Human Disease Laboratory are to analyze epigenetic signatures and explore their potential role in aging, multiorgan dysfunction syndromes and cancer development, adding diagnostic and prognostic value in order to help designing therapeutic approaches in an era of personalized medicine. The work is primarily focused on human cancer and sepsis with emphasis on basic research on human tissue and cells with a strong clinical association.
Chloe Gui, Justin Z Wang, Vikas Patil, Alexander P Landry, Olivia Singh, Pedro Castelo-Branco, Uri Tabori, Kenneth Aldape, Felix Behling, Jill S Barnholtz-Sloan, Craig Horbinski, Ghazaleh Tabatabai, Andrew Ajisebutu, Jeff Liu, Zeel Patel, Rebeca Yakubov, Ramneet Kaloti, Yosef Ellenbogen, Christopher Wilson, Aaron Cohen-Gadol,…Prof Gelareh Zadeh. Analysis of TERT association with clinical outcome in meningiomas: a multi-institutional cohort study (2025). DOI: 10.1016/S1470-2045(25)00267-0 Lancet Oncology (Q1; IF 35,9; Cit=1)
https://drive.google.com/file/d/1n3Rg_WPqNCPKouBsW1ewZmloC749Efwr/view?usp=sharing
Cândida Cardoso, Daniel Pestana, Sreemol Gokuladhas, Ana D Marreiros, Justin M O'Sullivan, Alexandra Binnie, Mónica T Fernandes and Pedro Castelo-Branco. Identification of Novel DNA Methylation Prognostic Biomarkers for AML With Normal Cytogenetics (2024). https://doi.org/10.1200/CCI.23.00265 JCO Clinical Cancer Informatics (Q1; IF 3,3; Cit=1)
https://drive.google.com/file/d/1kf1VDUjR5Z7kOSeFePZFqCopdeJXk8H_/view?usp=sharing
Joana Dias Apolónio, João S Dias, Mónica Teotónio Fernandes, Martin Komosa, Tatiana Lipman, Cindy H Zhang, Ricardo Leão, Donghyun Lee, Nuno Miguel Nunes, Ana-Teresa Maia, José L Morera, Luis Vicioso, Uri Tabori and Pedro Castelo-Branco. THOR is a targetable epigenetic biomarker with clinical implications in breast cancer (2022). 14:178; https://doi.org/10.1186/s13148-022-01396-3. Clinical Epigenetics (Q1; IF 4,8; Cit=11)
https://drive.google.com/file/d/17GeWBQpXlGTdBMQeUMGApyhclk_T_4DD/view?usp=sharing
Inês Faleiro, Vânia Palma Roberto, Secil Demirkol Canli, Nicolas A Fraunhoffer, Juan Iovanna, Ali Osmay Gure, Wolfgang Link and Pedro Castelo-Branco. DNA methylation of PI3K/AKT pathway-related genes predicts outcome in patients with pancreatic cancer: a comprehensive bioinformatics-based study. (2021). 13(24), 6354; https://doi.org/10.3390/cancers13246354. Cancers (Q1; IF 4,5; Cit=7)
https://drive.google.com/file/d/1OI7ZwH_HYY8ypSqSNGALo-agcKysW8Ua/view?usp=sharing
Donghyun D. Lee, Martin Komosa, Sumedha Sudhaman, Ricardo Leão, Cindy H. Zhang, Joana D. Apolonio, Thomas Hermanns, Peter J. Wild, Helmut Klocker, Farshad Nassiri, Gelareh Zadeh, Bill H. Diplas, Hai Yan, Steven Gallinger, Trevor J. Pugh, Vijay Ramaswamy, Michael D. Taylor, Pedro Castelo-Branco, Nuno Miguel Nunes, and Uri Tabori. Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer. (2021). 2021;131(21):e146915. https://doi.org/10.1172/JCI146915. Journal of Clinical Investigation (Q1; IF 13,3; Cit=15)
https://drive.google.com/file/d/11goIU68kYkhAs-UZKSIX285GLkMqK8yx/view?usp=sharing