Neurotransmission, synaptic plasticity and synaptopathies
Physiopathology of motor systems
Mechanisms underlying neuron sensitization to degenerate
Identification and development of feasible therapeutic strategies for treatment of several motor pathologies and neurodegenerative diseases.
qRT-PCR and Western Blotting
Interferent RNA technology applied to in vitro specimens and in live animals.
Primary cultures of spinal cord motoneurons obtained from mouse embryos.
Electrophysiological recordings of field and unique cell in in vitro samples and in the entire animal
Calcium imaging in culture cells
Immunohistochemistry
Intracerebral administration of oligonucleotides and drugs
Microiontophoresis in the central nevous system
Transgenic model of ALS disease: SOD1G93A
Knockout mice: task1-/-, task3-/-, task1-/-/task3-/-