ORPHY is part of the Institute of health-agro-material (IBSAM) of the Université de Bretagne Occidentale (UBO, Brest, France). The team studies cardiovascular and muscular adaptations, from cell to human in physiological and pathophysiological conditions. Clinical and fundamental approaches are used through in vivo and in vitro methodologies adapted to Health questions.
Our research activity is part of the Challenge 4 "Health and Welfare" as defined by the National Research Strategy France Europe 2020. Our investigations concern cardiovascular and muscular adaptations with the main objective of improving prevention and therapy in human. The main mechanisms studied concern metabolic (bioenergetics, inflammation, reactive oxygen species etc…), electrophysiological (ionic currents and excitability) and mechanical (contractility) aspects related to vascular and/or muscular functions. Studies are performed in various physiological and physiopathological conditions (see “research projects” sections)