Laboratory of Peptide Chemistry

Submitted by on Tue, 03/30/2021 - 14:44
Faculty of Chemistry/Department of Organic Chemistry/Peptide Chemistry Team
Size of the team
number of researchers number of supporting staff number of PhD students
PI name
Adam Prahl
Contact person and e-mail
Contact person
Adam Prahl
Contact person e-mail
Short description of research profile

peptide synthesis; structure-activity relationship studies; design and synthesis of proproteinconvertases inhibitors; design, synthesis and investigations on biological activity of  human b-defensin analogues; utilization of capillary electroforesis (CE) for identification of substances with different chemical properties, practical aspects of CE utilization


Representative publications

Design and structure–activity relationship of a potent furin inhibitor derived from influenza hemagglutinin Monika Lewandowska-Goch, Anna Kwiatkowska, Teresa Łepek, Kévin Ly, Navals Pauline, Gagnon Hugo, Yves Dory, Adam Prahl, Robert Day ACS Medicinal Chemistry Letters, 2021, 12(3), 365-372. DOI:10.1021/acsmedchemlett.0c00386
Is the use of surface-enhanced infrared spectroscopy justified in the selection of peptide fragments that play a role in substrate–receptor interactions? Adsorption of amino acids and neurotransmitters on colloidal Ag and Au nanoparticles Edyta Proniewicz, A. Ta̧ta, Emilia Iłowska, Adam Prahl Journal of Physical Chemistry B, 2021, 125(99), 2328-2338. DOI:10.1021/acs.jpcb.1c00546
Positional scanning identifies the molecular determinants of a high affinity multi-leucine inhibitor for furin and PACE4 Izabela Małuch, Christine Levesque, Anna Kwiatkowska, Frédéric Couture, Kévin Ly, Roxane Desjardins, Witold Neugebauer, Adam Prahl, Robert Day Journal of Medicinal Chemistry, 2017, 60(7), 2732-2744. DOI:10.1021/acs.jmedchem.6b01499
Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor Anna Kwiatkowska, Frédéric Couture, Christine Levesque, Kévin Ly, Roxane Desjardins, Sophie Beauchemin, Adam Prahl, Bernard Lammek, Witold Neugebauer, Yves L. Dory, Robert Day Journal of Medicinal Chemistry, 2014, 57(1), 98-109. DOI:10.1021/jm401457n
The multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells Christine Levesque, Martin Fugère, Anna Kwiatkowska, Frederick Couture, Roxane Desjardins, Sophie Routhier, Philippe Moussette, Adam Prahl, Bernard Lammek, Jon R. Appel, Richard A. Houghten, Francois D'Anjou, Yves Dory, Witold Neugebauer, Robert Day Journal of Medicinal Chemistry, 2012, 55(23), 10501-10511. DOI:10.1021/jm3011178