Laboratory of Biologically Active Compounds

Submitted by Krolicka on Thu, 05/13/2021 - 10:42
University
University of Gdańsk
Faculty/school/department
Intercollegiate Faculty of Biotechnology of the University of Gdansk and the Medical University of Gdansk
Size of the team
number of researchers number of supporting staff number of PhD students
3
0
3
PI
PI name
Aleksandra Królicka
PI email
aleksandra.krolicka@ug.edu.pl
PI bio

Aleksandra Królicka is Associate Professor and Head of the Laboratory of Biologically Active Compounds at the Intercollegiate Faculty of Biotechnology of the University of Gdansk and the Medical University of Gdansk, Poland. Its research topic focuses on: plant cell tissue, transformation, biologically active compounds, phytopharmaceuticals, synergistic combination of drugs, green synthesis of nanoparticles, drug resistance of bacteria.

Orcid: http://orcid.org/0000-0001-5231-283X

Research Gate: https://www.researchgate.net/profile/Aleksandra-Krolicka-3

Contact person and e-mail
Contact person
Aleksandra Królicka
Contact person e-mail
aleksandra.krolicka@ug.edu.pl
WWW
https://en.biotech.ug.edu.pl/research/research_groups/laboratory_biologically_a…
Short description of research profile

Our research is mostly focused on the development of new antimicrobial approaches to address the issue of bacterial infections in agriculture, as well as problem of multi-drug resistance in human and veterinary medicine. Currently we concentrate on the three major research areas:

1. Nanomaterials for treatment and prevention of infectious diseases.

2. Bioactive compound from plant origin.

3. Phage therapy for the control of agriculturally-relevant bacterial pathogens.

Research area
NATURAL SCIENCES » Biological sciences » (CQ) BIOCHEMISTRY & MOLECULAR BIOLOGY
NATURAL SCIENCES » Biological sciences » (DE) PLANT SCIENCES
NATURAL SCIENCES » Biological sciences » (QU) MICROBIOLOGY
Scientific Themes (keywords)
plant cell tissue
biologically active compounds
green synthesis of nanoparticles
drug resistance of bacteria
phytopharmaceuticals
synergistic combination of drugs
phage theraphy
plant microbe-interaction
biological control
bacteriophages
agriculture
toxicity
Caenorhabditis elegans
Publications

Representative publications

Makowski W, Królicka A, Nowicka A, Zwyrtková J, Tokarz B, Pecinka A, Banasiuk R, Tokarz KM. (2021). Transformed tissue of Dionaea muscipula J. Ellis as a source of biologically active phenolic compounds with bactericidal properties. Applied Microbiology and Biotechnology 105(3): 1215-1226  https://link.springer.com/article/10.1007/s00253-021-11101-8  
Krychowiak-Masnicka M, Krauze-Baranowska M, Godlewska S, Kaczynski Z, Bielicka-Giełdoń A, Grzegorczyk N, Narajczyk M, Frackowiak JE, Krolicka A. (2021). Potential of silver nanoparticles in overcoming the intrinsic resistance of Pseudomonas aeruginosa to secondary metabolites from carnivorous plants. International Journal of Molecular Sciences 22: 4849.  https://www.mdpi.com/1422-0067/22/9/4849 
Krzyzanowska DM, Maciag T, Siwinska J, Krychowiak M, Jafra S, Czajkowski R. (2019). Compatible Mixture of Bacterial Antagonists Developed to Protect Potato Tubers from Soft Rot Caused by Pectobacterium spp. and Dickeya spp. Plant Dis, 103(6), 1374-1382  https://apsjournals.apsnet.org/doi/full/10.1094/PDIS-10-18-1866-RE
Czajkowski R, Fikowicz-Krosko J, Maciag T, Rabalski L, Czaplewska P, Jafra S. et al. (2020). Genome-Wide Identification of Dickeya solani Transcriptional Units Up-Regulated in Response to Plant Tissues From a Crop-Host Solanum tuberosum and a Weed-Host Solanum dulcamara. [Original Research]. Front Plant Sci, 11(1368), 580330, doi:10.3389/fpls.2020.580330  https://www.frontiersin.org/articles/10.3389/fpls.2020.580330/full
Czajkowski R (2019). May the Phage be With You? Prophage-Like Elements in the Genomes of Soft Rot Pectobacteriaceae: Pectobacterium spp. and Dickeya spp. [Original Research]. Front Microbiol, 10(138), 138, doi:10.3389/fmicb.2019.00138.  https://www.frontiersin.org/articles/10.3389/fmicb.2019.00138/full

Link to extended list of publication

https://en.biotech.ug.edu.pl/research/research_groups/laboratory_biologically_a…
Technology Expertise
  • plant in vitro cultures
  • plant transformation
  • molecular biology
  • secondary metabolites extraction
  • phytochemical analyses (HPLC)
  • microbiology
  • antimicrobial susceptibility testing
  • bacterial biofilms
  • nanoparticle synthesis and characterization
  • C. elegans model in toxicity testing