University
Faculty/school/department
Faculty of Chemistry
PI name
Krzysztof Rolka
PI email
Contact person
Krzysztof Rolka
Contact person e-mail
Short description of research profile
Structure-activity relationship studies of biologically active peptides; design, chemical synthesis and biological activity of substrates and inhibitors of physiologically important enzymes – matriptase-2, matriptase-1, furin and proteasome; peptide conjugates with antimicrobial and anticancer activity – design and chemical activity; design and chemical synthesis peptides with enhance oral bioavailability
Research area
Scientific Themes (keywords)
Representative publications
Ptaszyńska N. Gucwa K., Olkiewicz K., Heldt M., Serocki M., Stupak A., Martynow D., Dębowski D., Gitlin-Domagalska A., Lica J., Łęgowska A., Milewski S., Rolka R., Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity, Int. J. Mol. Sci., 21, 4696 (2020); doi:10.3390/ijms21134696
Gitlin-Domagalska A., Dębowski D., Gucwa K., Starego D., Ptaszyńska N., Sieradzan A., Karczyńska A., A.Samsonow S., Mangold M., Gütschow M., Łęgowska A., RolkaK., Truncation of Huia versabilis Bowman-Birk inhibitor increases its selectivity, matriptase-1 inhibitory activity and proteolytic stability, Biochimie, 171–172, 178-186 (2020); doi: 10.1016/j.biochi.2020.03.006
Ptaszyńska N., Gucwa K., Olkiewicz K., Łȩgowska A., Okońska J., Ruczyński J., Gitlin-Domagalska A., Dȩbowski D., Milewski S., Rolka K., Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities, ACS Chem Biol. 14, 2233-2242 (2019); doi: 10.1021/acschembio.9b00538
Lubos M., Dębowski D., Bracińska E., Meid A., Inkielewicz-Stępniak I., Burster T., Rolka K., Inhibition of human constitutive 20S proteasome and 20S immunoproteasome with novel N-terminally modified peptide aldehydes and their antitumor activity, Biopolymers, 111(4), 2019, Article number e241002018; doi: 10.1002/pep2.24100
Ptaszyńska N., Gucwa K., Łęgowska A., Dębowski D., Gitlin-Domagalska A., Lica J., Heldt M., Martynow D., Olszewski M., Milewski S., Ng T.B., Rolka K., Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin, Bioconjugate Chem., 29, 3060-3071 (2018); doi: 10.1021/acs.bioconjchem.8b00440