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Laboratory of Bioorganic Chemistry

Submitted by k_rolka on
University
University of Gdańsk
Faculty/school/department
Faculty of Chemistry
Size of the team
number of researchers
5
number of supporting staff
0
number of PhD students
3
PI
PI name
Krzysztof Rolka
PI email
krzysztof.rolka@ug.edu.pl
PI bio

 https://orcid.org/0000-0002-4537-700X

Contact person and e-mail
Contact person
Krzysztof Rolka
Contact person e-mail
krzysztof.rolka@ug.edu.pl
WWW
https://chemia.ug.edu.pl/uniwersytet/struktura_ug/wydzial_chemii/katedra_bioche…
Short description of research profile

Structure-activity relationship studies of biologically active peptides; design, chemical synthesis and biological activity of substrates and inhibitors of physiologically important enzymes – matriptase-2, matriptase-1, furin and proteasome; peptide conjugates with antimicrobial and anticancer activity – design and chemical activity; design and chemical synthesis peptides with enhance oral bioavailability

Research area
NATURAL SCIENCES » Chemical sciences
Scientific Themes (keywords)
Peptides
peptidomimetics
conjugates
chemical synthesis
structure-activity-relationship studies
biological activity
inhibitors
antimicrobial
Publications

Representative publications

Ptaszyńska N. Gucwa K., Olkiewicz K., Heldt M., Serocki M., Stupak A., Martynow D., Dębowski D., Gitlin-Domagalska A., Lica J., Łęgowska A., Milewski S., Rolka R., Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity, Int. J. Mol. Sci., 21, 4696 (2020); doi:10.3390/ijms21134696

Gitlin-Domagalska A., Dębowski D., Gucwa K., Starego D., Ptaszyńska N., Sieradzan A., Karczyńska A., A.Samsonow S., Mangold M.,  Gütschow M., Łęgowska A., RolkaK., Truncation of Huia versabilis Bowman-Birk inhibitor increases its selectivity, matriptase-1 inhibitory activity and proteolytic stability, Biochimie, 171–172, 178-186 (2020); doi: 10.1016/j.biochi.2020.03.006

Ptaszyńska N., Gucwa K., Olkiewicz K., Łȩgowska A., Okońska J., Ruczyński J., Gitlin-Domagalska A., Dȩbowski D., Milewski S., Rolka K., Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities, ACS Chem Biol. 14, 2233-2242 (2019); doi: 10.1021/acschembio.9b00538

Lubos M., Dębowski D., Bracińska E., Meid A., Inkielewicz-Stępniak I., Burster T., Rolka K., Inhibition of human constitutive 20S proteasome and 20S immunoproteasome with novel N-terminally modified peptide aldehydes and their antitumor activity, Biopolymers, 111(4), 2019, Article number e241002018; doi: 10.1002/pep2.24100

Ptaszyńska N., Gucwa K., Łęgowska A., Dębowski D., Gitlin-Domagalska A., Lica J., Heldt M., Martynow D., Olszewski M., Milewski S., Ng T.B., Rolka K., Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin, Bioconjugate Chem., 29, 3060-3071 (2018); doi: 10.1021/acs.bioconjchem.8b00440