Expert in natural marine products. Her scientific interests focus on biomolecules produced by cyanobacteria. In the past, the aim of her studies was to gain in-depth knowledge of the role of cyanometabolites, including toxins, in functioning of aquatic environment. Most recent research is focused primarily on the potential application of selected cyanometabolites as pharmaceuticals (anticancer and antiviral agents). She was the initiator of setting up the Division of Marine Biotechnology at the University of Gdańsk, and since 2014 she has been the head of this unit. ORCID: 0000-0002-6526-4045
The recent research projects of the team have been focused on pharmaceutical application of marine natural products. The group explores the metabolic diversity of cyanobacteria in search for compounds, mainly oligopeptides, of anticancer and antiviral activities. In a wide collaboration with other partners, the possible mechanism of cyanopeptides action, the alternativie methods of production as well as the behaviour under physiological conditions are studied.
Mass spectrometry, analytical and preparative chromatography, genetic analysis, biological and biochemical assays, culture collection of microorganisms.
Mazur-Marcze H., Fidor A., Cegłowska M., Wieczerzak E., Kropidłowska M., Goua M., Macaskill J., Edwards C., 2018, Cyanopeptolins with Tripsin and Chymotripsin Inhibitory activity from Cyanobacterium Nostoc edaphicum CCNP1411, Marine Drugs 2018, 16(7):220; http://www.mdpi.com/1660-3397/16/7/220
Fidor A., Konkel R., Mazur-Marzec H., 2019, Bioactive Peptides Produced by Cyanobacteria of the Genus Nostoc: A Review. Marine Drugs 17(10), 561 https://doi.org/10.3390/md17100561
Mazur-Marzec H., Bertos-Fortis M., Toruńska-Sitarz A., Fidor A., Legrand C., 2016, Chemical and Genetic Diversity of Nodularia spumigena from the Baltic Sea. Marine Drugs, 14(11): 209; doi:10.3390/md14110209; http://www.mdpi.com/1660-3397/14/11/209
Šulčius S., Mazur-Marzec H., Vitonytė I., Kvederavičiūtė K., Kuznecova J., Šimoliūnas E, Holmfeldt K., 2018, Insights into cyanophage-mediated dynamics of nodularin and other non-ribosomal peptides in Nodulria spumigena. Harmful algae 78: 69-74 https://doi.org/10.1016/j.hal.2018.07.004
Zervou S.-K, Gkelis S., Kaloudis T., Hiskia A., Mazur-Marzec H., 2020, New microginins from cyanobacteria of Greek freshwaters, Chemosphere (2020), https://doi.org/10.1016/j.chemosphere.2020.125961