Chronic Inflammation

The interaction of antigen-specific T and B cells is key for an effective adaptive immune response. T follicular helper (Tfh) cells are the T cell subset that provide B cell assistance during the germinal center reaction. Tfh cells are the prerequisite for the generation of high-affinity memory B cells and long-lived plasma cells. Therefore, manipulation of the Tfh response is of particular clinical interest for aiding in the generation of protective antibodies during vaccination or for eliminating harmful antibodies in autoimmune diseases and allergies [1].