neurodegeneration

Our research group focuses on diseases related to the aggregation of polypeptides and proteins. We study the aggregation process itself using fluorescence and electrophoretic methods, size-exclusion chromatography, and LC-MS coupled with enzymatic digestion. We are also deeply involved in the search for aggregation inhibitors as well as in studying the role that the 20S proteasome, stimulated by the activators we design, may play in removing toxic soluble oligomers.

• Role of mitocondria in ROS and RNS generation and its influence in aging and neurodegeneration.
• Risk factors related with the neurodegenerative diseases.
• Involvement of homocysteine in cell an tissue damage