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Department of Biomedical Chemistry_EJ

Submitted by elzbieta.janko… on

Research Areas & Expertise

MEDICAL AND HEALTH SCIENCES » Basic medical research

synthesis of peptides and peptidomimetics

organic synthesis

HPLC

FTIR

protein crystallography

electrophoresis

 

 

Principal Investigator

Elzbieta Jankowska

elzbieta.jankowska@ug.edu.pl

orcid.org/0000-0002-1099-8885

Faculty/school/department
Faculty of Chemistry
PI bio

orcid.org/0000-0002-1099-8885

PI name
Elzbieta Jankowska
Short description of research profile

Our research group focuses on diseases related to the aggregation of polypeptides and proteins. We study the aggregation process itself using fluorescence and electrophoretic methods, size-exclusion chromatography, and LC-MS coupled with enzymatic digestion. We are also deeply involved in the search for aggregation inhibitors as well as in studying the role that the 20S proteasome, stimulated by the activators we design, may play in removing toxic soluble oligomers. We evaluate the activation capacity of the modulators both in vitro, using the proteasome isolated from human erythrocytes, and in cells transfected with plasmids encoding aggregation-prone proteins.  

Contact person
Elzbieta Jankowska
Contact person e-mail
Scientific Themes (keywords)
Technology Expertise

synthesis of peptides and peptidomimetics

organic synthesis

HPLC

FTIR

protein crystallography

electrophoresis

 

 

Osmulski Paweł A., Karpowicz Przemysław, Jankowska Elżbieta, Bohmann Jonathan, Pickering Andrew M., Gaczynska Maria

New peptide-based pharmacophore activates 20S proteasome

Molecules 25: 1-17, 1439 (2020)

DOI:10.3390/molecules25061439

Sandra Skibiszewska, Szymon Żaczek, Agnieszka Dybala-Defratyka, Katarzyna Jędrzejewska, Elżbieta Jankowska

Influence of short peptides with aromatic amino acid residues on aggregation properties of serum amyloid A and its fragments.

Arch. Biochem. Biophys. 681: 108264-108272 (2020)

DOI: 10.1016/j.abb.2020.108264

Małgorzata Giżyńska, Julia Witkowska, Przemysław Karpowicz, Rafał Rostankowski, Estrella S. Chocron, Andrew M. Pickering, Pawel Osmulski, Maria Gaczynska, Elżbieta Jankowska

Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity

J. Med. Chem. 62: 359-370 (2019)

DOI: 10.1021/acs.jmedchem.8b01025

Witkowska, J.,Gizynska, M.,Grudnik, P.,Golik, P.,Karpowicz, P.,Giedon, A.,Dubin, G., Jankowska, E.

Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome - insights into the enzyme activation mechanism

Sci Rep 7: 6177 (2017)

DOI: 10.1038/s41598-017-05997-4

Orlikowska M., Szymańska A., Borek D., Otwinowski Z., Skowron P., Jankowska E.

Structural characterization of V57D and V57P mutants of human cystatin C, an amyloidogenic protein

Acta Cryst. D69, 577-586 (2013)

DOI: 10.1107/S0907444912051657

number of researchers
7
number of supporting staff
0
number of PhD students
2
Size of the team