The scopes of research include spectrophotometric and spectrofluorimetric methods for the determination of antioxidative potential of different substrates including in vitro, ex vivo and in vivo samples like human blood (plasma, serum), tissues (animal, human) and different herbals. Recent research by this group has been focused on skin models of damages (mechanical, UV, chemical) and on various treatment potential of different substances for skin.
The main scope of our research is to evaluate the new emerging method of pain monitoring in ophthalmological practice. Our research is conducted in collaboration with prof.Hanne Storm from University of Oslo,Norway, School of Medicine who has developed the skin conductance pain monitoring device and prof.Goran Petrovski, from University of Oslo, Oslo University hospital- Department of Ophthalmology and Centre for eye research.
First identified genetic variants for most thyroid hormones/antibodies have been recently published by our research group. For now, only 5.34% of genetic variance has been explained for parathyroid hormone (PTH) levels while calcitonin and osteocalcin, which together with PTH regulate blood calcium homeostasis, have not been analysed on a genome-wide level. Prediction analyses have gained increasing significance over the last few years. The aim of such analyses is to predict the value of a quantitative trait based on genetic and environmental parameters.
The Dental Biomaterials and Oral Care Products is research group that primarily focuses on possible biological side effects of diverse kinds of biomaterials, as well oral care products. So far, we have been investigating the toxicity of dental composites, adhesive systems, and glass-ionomer cements ex vivo on human pulp fibroblast, gingival fibroblasts, and lymphocytes (micronucleus and comet assay). However, all ex vivo studies are conducted under strictly controlled conditions, and those results should be taken with caution.
Laboratory for cellular physiology was established at Department of Physiology in 2008 by Drs. Jasna Marinović and Marko Ljubković. Research focus of the laboratory have been intracellular processes involved in ischemic cardiac disease as well as various modes of cardiac protection. Also, myocardial metabolic variations are being investigated in different pathological conditions (such as diabetes) or as part of a so called cardiac metabolic therapy.
We investigate the roles of extracellular matrix (ECM) components from the glycosaminoglycan (GAG) class, enzymes for biosynthesis of GAGs and cell surface receptors of GAGs in the regulation of inflammatory response in generalized destructive form of periodontal disease in humans
ORPHY is part of the Institute of health-agro-material (IBSAM) of the Université de Bretagne Occidentale (UBO, Brest, France). The team studies cardiovascular and muscular adaptations, from cell to human in physiological and pathophysiological conditions. Clinical and fundamental approaches are used through in vivo and in vitro methodologies adapted to Health questions.
Our research includes two main fields of interest: research related to the photodynamic inactivation (PDI) of bacterial infections as well as the application of modern tools of molecular biology in the study of stem cells, cancer, metabolic and infectious diseases. PDI is based on the concept that metabolically active cells, like bacteria, fungi accumulate a photosensitizer (PS), a small molecular compound, which is excited by visible light.