Nephrology Unit in Dept. of General and Medical Biochemistry

Submitted by Marlena Typiak on Tue, 06/07/2022 - 11:57
Faculty/school/department
Department of General and Medical Biochemistry, Faculty of Biology
Size of the team
number of researchers number of supporting staff number of PhD students
1
0
0
PI
Contact person and e-mail
Contact person
Marlena Typiak
Contact person e-mail
Short description of research profile

I am currently working on the immunologic features of human podocytes, as well as role of Klotho and NPP1 proteins in the course of diabetic nephropathy. Previously, I studied genetics and immunology of sarcoidosis and tuberculosis. I work with cell lines, I perform quantitative analyses of gene and protein expression. I also implement techniques like immunofluorescence and immunohistochemistry, and analyse glycolitic parametres of podocytes by measurement of extracellular acidification.

Publications

Representative publications

1. Typiak M., Kulesza T., Rachubik P., Rogacka D., Audzeyenka I., Angielski S., Saleem M.A., Piwkowska A. Role of Klotho in hyperglycemia: its levels and effects on fibroblast growth factor receptors, glycolysis, and glomerular filtration. Int. J. Mol. Sci. 2021;22:  7867. doi.org/10.3390/ijms22157867.  https://www.mdpi.com/1422-0067/22/15/7867
2. Typiak M., Piwkowska A. Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy. Int. J. Mol. Sci. 2021;22(2): 956. doi:10.3390/ijms22020956.  https://www.mdpi.com/1422-0067/22/2/956
3. Typiak M., Rębała K., Haraś A., Skotarczak M., Słomiński J. M., Dubaniewicz A. Copy number variation of FCGR genes in etiopathogenesis of sarcoidosis. PLoS ONE 2017;12(5): e0177194.  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177194
4. Typiak M., Rebala K., Dudziak M., Dubaniewicz A. Polymorphism of FCGR2A, FCGR2C and FCGR3B genes in the etiopathogenesis of sarcoidosis. Adv Exp Med Biol 2016;905: 57-68.  https://link.springer.com/chapter/10.1007/5584_2015_193  
5. Typiak M.J., Rębała K., Dudziak M., Dubaniewicz A. Polymorphism of FCGR3A gene in sarcoidosis. Hum Immunol 2014;75: 283-288.  https://www.sciencedirect.com/science/article/abs/pii/S0198885914000810?via%3Dihub

Link to extended list of publication