We investigate the roles of extracellular matrix (ECM) components from the glycosaminoglycan (GAG) class, enzymes for biosynthesis of GAGs and cell surface receptors of GAGs in the regulation of inflammatory response in generalized destructive form of periodontal disease in humans
ORPHY is part of the Institute of health-agro-material (IBSAM) of the Université de Bretagne Occidentale (UBO, Brest, France). The team studies cardiovascular and muscular adaptations, from cell to human in physiological and pathophysiological conditions. Clinical and fundamental approaches are used through in vivo and in vitro methodologies adapted to Health questions.
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Born from the complementarity between the field of health and the communication sciences, the LaTIM ("laboratoire de traitement de l’information médicale" for laboratory of medical information processing) develops a multidisciplinary research driven by members from University of Western Brittany, IMT Atlantique, INSERM and Brest CHRU (university hospitals).
The project of INSERM Unit 1078 is to enable a better understanding of the genetic and pathophysiological bases of some human genetic diseases, for example cystic fibrosis, hemochromatosis, hereditary chronic pancreatitis or some mitochondrial pathologies.
The ambition of our research project from gene to patient is to decipher the relationship between the structure of the genes and their function and between genotype and phenotype. To carry out these projects, Unit 1078 relies on: