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CTS562: Neurobiology Lab

Submitted by francisco.grimaldi on

Research Areas & Expertise

MEDICAL AND HEALTH SCIENCES » Basic medical research

In vivo two-photon microscopy.

Techniques for the study of animal behavior

Molecular biology techniques

Cell Biology techniques

Histological techniques

Patch-Clamp electrophysiological recordings of neuronal activity

Principal Investigator

CARMEN CASTRO GONZALEZ

carmen.castro@uca.es

 

INDICATORS: h-index: (18 Scopus; 19 Google Academics)

ORCID ID: 0000-0002-6802-0572

University
Faculty/school/department
FACULTY OF MEDICINE/ BIOMEDICINE, BIOTECHNOLOGY AND PUBLIC HEALTH/ PHYSIOLOGY
PI bio

 

INDICATORS: h-index: (18 Scopus; 19 Google Academics)

ORCID ID: 0000-0002-6802-0572

Composition of Joint Unit of Research

The PAIDI CTS 562 group is conformed by two research teams with lines of investigation funded in competitive National and International calls led by Dr. Carmen Castro González and Mónica García Alloza. The research of this group is aimed at studying the molecular and cellular mechanisms underlying pathologies of the nervous system, including neurodegenerative diseases such as Alzheimer's disease, diabetes mellitus type II, or amyotrophic lateral sclerosis. In addition, the mechanisms that regulate neurogenesis and glyogenesis in brain injuries caused by traumatic or ischemic lesions are studied, as well as neurogenesis in other brain regions in which the loss of neurons during aging results incognitive decline. In addition to the basic studies, the group is also working on the search for therapeutic options for the treatment of the above-mentioned pathologies.

In relation to productivity indicators, the group that has been continuously funded in competitive public calls both at regional and national level and in calls H2020 (4-5 grants per year in the last 5 years) has an average of 7 indexed publications per year in the last 5 years, has submitted 8 patent applications and has significant funding from private entities through technology transfer contracts. In relation to international collaborations, the group maintains close collaborations with groups of prestigious universities at international level such as Harvard University in the USA, Oxford University and Edinburgh University in the UK and Tsukuba University in Japan among others.

PI name
CARMEN CASTRO GONZALEZ
Short description of research profile

The retina as a diagnostic window in Alzheimer's disease and type 2 diabetes mellitus.

Type 2 diabetes mellitus, vascular dementia and Alzheimer's disease: interrelationship and mechanisms involved .

Mechanisms of beta-amyloid deposition in murine models of Alzheimer's disease

Design of drugs for the regeneration of brain injuries.

Neuroregeneration: study of the molecular mechanisms underlying the process of generating new neurons in brain injuries.

Characterization of experimental models of intraventricular hemorrhage of the preterm newborn, therapeutic considerations.

Biochemical and functional markers of hypoxic-ischaemic damage in the newborn.

Oxidative stress and neuroinflammation as a cause of neurodegenerative disease

Contact person
CARMEN CASTRO GONZALEZ
Contact person e-mail
Technology Expertise

In vivo two-photon microscopy.

Techniques for the study of animal behavior

Molecular biology techniques

Cell Biology techniques

Histological techniques

Patch-Clamp electrophysiological recordings of neuronal activity

1. A NOVEL OMEGA-3-ACID ETHYL ESTER FORMULATION INCORPORATING ADVANCED LIPID TECHNOLOGIESTM (ALT®) IMPROVES DOCOSAHEXAENOIC ACID AND EICOSAPENTAENOIC ACID BIOAVAILABILITY COMPARED WITH LOVAZA®

Miguel A. Lopez-Toledano, PhD ,Thorsteinn Thorsteinsson, PhD,,Ahmed Daak, MD, MSc, PhD, Kevin C. Maki, PhD, Colleen Johns, BS, Adrian L. Rabinowicz, MD, Frederick D. Sancilio, PhD

 VOLUME 39, ISSUE 3, P581-591, MARCH 01, 2017

number of researchers
14
number of supporting staff
0
number of PhD students
0
Size of the team