CTS562: Neurobiology Lab

Submitted by francisco.grimaldi on Tue, 07/07/2020 - 15:02
University
Faculty/school/department
FACULTY OF MEDICINE/ BIOMEDICINE, BIOTECHNOLOGY AND PUBLIC HEALTH/ PHYSIOLOGY
Size of the team
number of researchers number of supporting staff number of PhD students
14
0
0
Composition of Joint Unit of Research, if relevant

The PAIDI CTS 562 group is conformed by two research teams with lines of investigation funded in competitive National and International calls led by Dr. Carmen Castro González and Mónica García Alloza. The research of this group is aimed at studying the molecular and cellular mechanisms underlying pathologies of the nervous system, including neurodegenerative diseases such as Alzheimer's disease, diabetes mellitus type II, or amyotrophic lateral sclerosis. In addition, the mechanisms that regulate neurogenesis and glyogenesis in brain injuries caused by traumatic or ischemic lesions are studied, as well as neurogenesis in other brain regions in which the loss of neurons during aging results incognitive decline. In addition to the basic studies, the group is also working on the search for therapeutic options for the treatment of the above-mentioned pathologies.
In relation to productivity indicators, the group that has been continuously funded in competitive public calls both at regional and national level and in calls H2020 (4-5 grants per year in the last 5 years) has an average of 7 indexed publications per year in the last 5 years, has submitted 8 patent applications and has significant funding from private entities through technology transfer contracts. In relation to international collaborations, the group maintains close collaborations with groups of prestigious universities at international level such as Harvard University in the USA, Oxford University and Edinburgh University in the UK and Tsukuba University in Japan among others.

PI
PI name
CARMEN CASTRO GONZALEZ
PI bio

 

INDICATORS: h-index: (18 Scopus; 19 Google Academics)

ORCID ID: 0000-0002-6802-0572

Contact person and e-mail
Contact person
CARMEN CASTRO GONZALEZ
Contact person e-mail
WWW
Short description of research profile

The retina as a diagnostic window in Alzheimer's disease and type 2 diabetes mellitus.
Type 2 diabetes mellitus, vascular dementia and Alzheimer's disease: interrelationship and mechanisms involved .
Mechanisms of beta-amyloid deposition in murine models of Alzheimer's disease
Design of drugs for the regeneration of brain injuries.
Neuroregeneration: study of the molecular mechanisms underlying the process of generating new neurons in brain injuries.
Characterization of experimental models of intraventricular hemorrhage of the preterm newborn, therapeutic considerations.
Biochemical and functional markers of hypoxic-ischaemic damage in the newborn.
Oxidative stress and neuroinflammation as a cause of neurodegenerative disease

Publications

Representative publications

1. A NOVEL OMEGA-3-ACID ETHYL ESTER FORMULATION INCORPORATING ADVANCED LIPID TECHNOLOGIESTM (ALT®) IMPROVES DOCOSAHEXAENOIC ACID AND EICOSAPENTAENOIC ACID BIOAVAILABILITY COMPARED WITH LOVAZA® Miguel A. Lopez-Toledano, PhD ,Thorsteinn Thorsteinsson, PhD,,Ahmed Daak, MD, MSc, PhD, Kevin C. Maki, PhD, Colleen Johns, BS, Adrian L. Rabinowicz, MD, Frederick D. Sancilio, PhD  VOLUME 39, ISSUE 3, P581-591, MARCH 01, 2017

Link to extended list of publication

Technology Expertise

In vivo two-photon microscopy.
Techniques for the study of animal behavior
Molecular biology techniques
Cell Biology techniques
Histological techniques
Patch-Clamp electrophysiological recordings of neuronal activity