Medicinal Chemistry Laboratory

Submitted by Sylwia on Tue, 03/30/2021 - 23:14
Photo of the research group
Faculty of Chemistry
Size of the team
number of researchers number of supporting staff number of PhD students
PI name
Sylwia Rodziewicz-Motowidło
Contact person and e-mail
Contact person
Sylwia Rodziewicz-Motowidło
Contact person e-mail
Short description of research profile

Human Cystatin C - conformational studies using NMR techniques and molecular dynamics
Study of the interaction of human cystine C with antibodies as potential amyloidosis inhibitors
Peptide antibiotics and peptidomimetics - design, synthesis, conformational studies
Peptides with pro-regenerative and neuroprotective properties - design, synthesis and physicochemical research
Design, synthesis and research of peptides with potential anti-cancer properties
Peptides and peptidomimetics in viral diseases
Design, synthesis and biological research of antibacterial, antiviral and antifungal compounds.
Design, synthesis and biological studies of inhibitors of the osteoporosis process.
Design, synthesis and studies of the activity of cysteine ​​protease inhibitors.
Synthesis and research of peptides with proproliferative properties
Design and synthesis of inhibitors of the formation of BTLA-HVEM, CD160-HVEM, PD1-PDL1 protein complexes with potential application in cancer immunotherapy.
Searching for inhibitors of amyloidogenic protein aggregation, such as serum amyloid A protein and beta-amyloid peptide
Design, synthesis and biological research of antibacterial and antiviral compounds together with the study of their mechanism of action;
Peptides stimulating regeneration - synthesis and research on stimulating the growth of fibroblasts.
Structural studies of HVEM / CD160 signaling receptors as potential targets of immunotherapy;
Investigation of the degradation process of protein aggregates by determining the spatial structure of the Hsp104 heat shock protein.
Determination of spatial structures of proteins and their complexes by means of X-ray structure;

Technology Expertise

peptide synthesis, organic synthesis, structural studies, SAR studies, mass spectrometry, X-ray crystallography, NMR spectroscopy, IR spectroscopy, CD spectroscopy, fluorescence, ELISA tests, ligand-protein interaction studies, drug design, aggregation tests, HPLC, LC-MS, SEC analysis