(NI) IMMUNOLOGY

The interaction of antigen-specific T and B cells is key for an effective adaptive immune response. T follicular helper (Tfh) cells are the T cell subset that provide B cell assistance during the germinal center reaction. Tfh cells are the prerequisite for the generation of high-affinity memory B cells and long-lived plasma cells. Therefore, manipulation of the Tfh response is of particular clinical interest for aiding in the generation of protective antibodies during vaccination or for eliminating harmful antibodies in autoimmune diseases and allergies [1].

I am currently working on the immunologic features of human podocytes, as well as role of Klotho and NPP1 proteins in the course of diabetic nephropathy. Previously, I studied genetics and immunology of sarcoidosis and tuberculosis. I work with cell lines, I perform quantitative analyses of gene and protein expression. I also implement techniques like immunofluorescence and immunohistochemistry, and analyse glycolitic parametres of podocytes by measurement of extracellular acidification.

Human Cystatin C - conformational studies using NMR techniques and molecular dynamics
Study of the interaction of human cystine C with antibodies as potential amyloidosis inhibitors
Peptide antibiotics and peptidomimetics - design, synthesis, conformational studies
Peptides with pro-regenerative and neuroprotective properties - design, synthesis and physicochemical research
Design, synthesis and research of peptides with potential anti-cancer properties
Peptides and peptidomimetics in viral diseases

Intracellular signaling in T-lymphocytes

Genomics in Intracellular signaling and immune tolerance induction
Gene and Cell Immunetherapy
Chimeric Antigen Receptors (CAR)

We investigate the roles of extracellular matrix (ECM) components from the glycosaminoglycan (GAG) class, enzymes for biosynthesis of GAGs and cell surface receptors of GAGs in the regulation of inflammatory response in generalized destructive form of periodontal disease in humans