(UM) PHYSIOLOGY

The research activities of the Biological Sciences group focus on the following main areas.

1) Identification of new molecules targeting enzymes involved in neurodegenerative diseases and cancer.

2) Central and local control of reproduction in mammalian and non-mammalian vertebrates by cannabinoids, environmental pollutants and endocrine disruptors.

The work of EA4685 concerns the control of the nervous system over the physiology of organs, mainly sensory organs, neuronal plasticity and the interactions of cells of the nervous system (neurons and glial cells) with other cells. These aspects are addressed by biology, biotechnology, physiology and pathophysiology.
Most of our work concerns the relationships between the skin and the nervous system for the understanding of pruritus.

Neurotransmission, synaptic plasticity and synaptopathies
Physiopathology of motor systems
Mechanisms underlying neuron sensitization to degenerate
Identification and development of feasible therapeutic strategies for treatment of several motor pathologies and neurodegenerative diseases.

The retina as a diagnostic window in Alzheimer's disease and type 2 diabetes mellitus.
Type 2 diabetes mellitus, vascular dementia and Alzheimer's disease: interrelationship and mechanisms involved .
Mechanisms of beta-amyloid deposition in murine models of Alzheimer's disease
Design of drugs for the regeneration of brain injuries.
Neuroregeneration: study of the molecular mechanisms underlying the process of generating new neurons in brain injuries.

http://www.mefst.unist.hr/research/research-groups-and-laboratories/neuroscience-and-sleep/5062

1. Basic research of respiratory and cardiovascular systems and mechanisms of hypoxia- or hypercapnia-induced respiratory neuroplasticity (animal in vivo research).

Laboratory for cellular physiology was established at Department of Physiology in 2008 by Drs. Jasna Marinović and Marko Ljubković. Research focus of the laboratory have been intracellular processes involved in ischemic cardiac disease as well as various modes of cardiac protection. Also, myocardial metabolic variations are being investigated in different pathological conditions (such as diabetes) or as part of a so called cardiac metabolic therapy.

We investigate the roles of extracellular matrix (ECM) components from the glycosaminoglycan (GAG) class, enzymes for biosynthesis of GAGs and cell surface receptors of GAGs in the regulation of inflammatory response in generalized destructive form of periodontal disease in humans

ORPHY is part of the Institute of health-agro-material (IBSAM) of the Université de Bretagne Occidentale (UBO, Brest, France). The team studies cardiovascular and muscular adaptations, from cell to human in physiological and pathophysiological conditions. Clinical and fundamental approaches are used through in vivo and in vitro methodologies adapted to Health questions.